Of ancient foundation, the church of Santi Domenico e Sisto, which is dedicated to St Dominic and Pope St Sixtus II (r. 257-8), was built in the early 17th century.
A Detail of the Facade
The inscription on the facade proclaims: B[eato] · P[atri] · DOMIN[ico] · ORD[inis] · PRAED[icatorum] · FV[n] · DAT[ori] · ET · MONIALIVM · PARENTI · D[icata].
In between the doorcase and the pediment is a tablet bearing a relief of a dog. This is a pun on the name of the Dominicans - Domini Canes (Dogs of the Lord).
The Facade is Crowned with the Head of an Angel
The four statues on the facade depict PopeSt SixtusII &St Dominic (lower) and St Peter Martyr &St Thomas Aquinas (see below).
Nave
The interior is a single nave with a rectangular apse.
The vault of the apse has a fresco which continues onto the back wall. It depicts The Heavenly Patronage of the Dominican Order, the work of Domenico Maria Canuti (1625-84).
Vault
The ceiling was painted by Domenico Maria Canuti and Enrico Haffner. The central scene depicts the Apotheosis of St Dominic (1674).
Noli Me Tangere by Antonio Raggi
The beautiful sculpture of Noli Me Tangere (1649), in the Cappella Alaleona (first right), is by Antonio Raggi (1624-86).