Of ancient foundation, the church of Santi Domenico e Sisto, which is dedicated to St Dominic and Pope St Sixtus II (r. 257-8), was built in the early 17th century.
The inscription on the facade proclaims: B · P · DOMIN · ORD · PRAED · FU · DAT · ET · MONIALIVM · PARENTI · D. The four statues depict St Dominic and PopeSt SixtusII (lower) and St Thomas Aquinas and St Peter Martyr.
The interior is a single nave with a rectangular apse. The ceiling was painted by Domenico Maria Canuti and Enrico Haffner. The central scene depicts the Apotheosis of St Dominic (1674). Canuti also painted the fresco of the Heavenly Patronage of the Dominican Order in the vault of the apse.
The beautiful sculpture of Noli Me Tangere (1649), in the Cappella Alaleona (first right), is by Antonio Raggi.