The ancient church of San Crisogono, which is dedicated to St Chrysogonous, was founded in the 5th century. It was rebuilt in the early 12th century by its titular cardinal Giovanni da Crema. The campanile survives from this rebuilding. In 1623 the church was reconstructed by Giovanni Battista Sora for Cardinal Scipione Borghese, the immensely wealthy nephew of Pope Paul V (r. 1605-21).
Twenty-two ancient columns separate the nave from the aisles. The triumphal arch is supported by a pair of porphyry columns. The 13th century Cosmatesque pavement is one of the finest in Rome.
The baldacchino was designed by Sora. The mosaic on the wall of the apse, attributed to the school of Pietro Cavallini, depicts the Virgin and Child flanked by St James and St Chrysogonous.