The ancient church of San Lorenzo in Damaso is believed to have been founded in the home of Pope St Damasus I (r.366-84). The church was destroyed at the end of the 15th century for the construction of Palazzo della Cancelleria, and rebuilt (1485-96) as part of the fabric of the palazzo.
San Lorenzo in Damaso has no facade; entry is through a simple doorway. Inside, a double atrium precedes the very wide nave. The painting on the high altar is the Coronation of the Virgin Mary (1568) by Federico Zuccari (1539-1609).