The 17th century hospital church of San Rocco all' Augusteo was designed by the Roman architect Giovan Antonio de' Rossi (1616-95). The façade was only added in 1834 with a neo-classical design by another Roman architect, Giuseppe Valadier (1762-1839). The central door is surmounted by the coat-of-arms of Pope Gregory XVI (r. 1831-46).
The side doors are surmounted by large tablets. The left tablet reads: SEDENTE /GREGORIO · XVI · P · M / FRONS · TEMPLI / B · ROCHO / PESTE · INFECTIS / OPIFERO / DICATI / IOSEPHI · VITELLI / AEDE · LEGATO / A · FUNDAMENTIS / ERECTA · ABSOLUTA / A · D · MDLCCCXXXIIII (During the reign of Pope Gregory XIV, the facade of the temple dedicated to St Roch, the helper of those infected with the plague, was erected complete from its foundations by Joseph Vitelli, Superior of the House, in the year 1834).
The right tablet reads: NE · DIRA · ATTINGAT / MORTALIA · CORPORA / PESTIS / SORDIDA · NE · FOEDENT / IMMORTALES · ANIMOS / CRIMINA / PRECIBUS · AGE · TUIS / INCLITE ROCHE (So that dangerous plague does not affect mortal bodies and dirty bad actions pollute immortal souls, act with your prayers venerable Roch).
Nave
The interior comprises a nave, a domed transept and a sanctuary. There are three self-contained chapels on each side of the nave and an altar at each end of the transept.
The ceiling of the nave is barrel-vaulted; the large painting in the centre of the vault depicts The Funeral and Apotheosis of St Roch (1864) by Achille Scaccioni.
High Altar
The high altar depicts The Apotheosis of St Roch by Giacinto Brandi (1621-91). The frescoes (1885) on the walls of the sanctuary are by Cesare Mariani and depict St Roch in a Hospital and St Martin Sharing His Cloak with a Beggar.
Dome
The frescoes in the dome are the work of Francesco Rosa.