In 1729,the church of San Gregorio della Divina Pietà was restored by the Roman architect and sculptor Filippo Barigioni (c. 1680-1753), at the behest of Pope Benedict XIII (r. 1724-30), and given to the Operai della Divina Pietà (Workers of Divine Mercy), which had been founded in 1679 to help families who were once well-off, but who had fallen into poverty
Alms Slot
There is an alms slot on the north wall with the inscription: ELEMOSINA PER POVERE ONORATE FAMIGLIE E VERGOGNOSE (Alms for poor, honourable and embarrassed families). There is another slot on the same wall which is inscribed: MEMORIALI. This was for people to give the names of persons or families in difficulty.
San Gregorietto, as the church is also known (on account of its small size), stands outside what was once the Jewish Ghetto. On its facade there is an inscription from the Book of Isaiah in both Hebrew and Latin. It reads in translation: 'I have spread out my hands all the day unto a rebellious people, which walketh in a way that was not good, after their own thoughts; A people that provoketh me to anger continually to my face; that sacrificeth in gardens, and burneth incense upon altars of brick' (Isaiah, 65: 2-3, KJV).
San Gregorio della Divina Pietà is also known as San Gregorio a Ponte Quattro Capi, on account of its proximity to the Bridge of the Four Heads, a name given to the ancient Ponte Fabricio.