The altarpiece is a copy, in mosaic, of a work by Domenico Zampieri (1581-1641), better known as Domenichino. All of the altarpieces in the basilica are copies, in mosaic, of original paintings. The only exception, an oil painting by Pietro da Cortona, can be found in the Chapel of the Blessed Sacrament.
Under the altar lies the body of Pope John Paul II (r. 1978-2005), which was placed here following his beatification in May, 2011. He was canonised on April 27th, 2014.